DNA methylation generally functions as a repressive transcriptional signal, but it is also known to activate gene expression. In either case, the downstream factors remain largely unknown. By using comparative interactomics, we isolated proteins in Arabidopsis thaliana that associate with methylated DNA. Two SU(VAR)3-9 homologs, the transcriptional antisilencing factor SUVH1, and SUVH3, were among the methyl reader candidates. SUVH1 and SUVH3 bound methylated DNA in vitro, were associated with euchromatic methylation in vivo, and formed a complex with two DNAJ domain-containing homologs, DNAJ1 and DNAJ2. Ectopic recruitment of DNAJ1 enhanced gene transcription in plants, yeast, and mammals. Thus, the SUVH proteins bind to methylated DNA and recruit the DNAJ proteins to enhance proximal gene expression, thereby counteracting the repressive effects of transposon insertion near genes.
[转载出处:www.11jj.com]
Quantifying the contribution of recessive coding variation to developmental disorders [好文分享:www.11jj.com]
科学家解密发育障碍的遗传结构
▲ 作者:Hilary C. Martin, Wendy D. Jones, Rebecca McIntyre, et al
▲ 链接:
http://science.sciencemag.org/content/362/6419/1161
▲ 摘要:
发育障碍(DDs)的遗传学机制非常复杂。
研究人员对6040个有发育障碍的家庭进行外显子组测序,评估其中隐性编码变异可能起到的作用,发现可归因于隐性编码变异的案例比例较先前估算的更低。
大家好,小美今天来为大家解答内江公需科目继续教育登录入口官网以下问题,内江市公需科目考试网很多人还不知道,现在让我们一起来看看吧!
大家好,小乐今天来为大家解答第四门八门遁甲以下问题,八门遁甲第四门叫什么很多人还不知道,现在让我们一起来看看吧!1、八门遁甲中的第四
为了流量,毫无底线编造“怙恃双亡”人设骗取网友同情和爱心卖的居然照样假货……近日拥有近400万粉丝的主播“凉山孟阳”及其团伙等8人均获刑
大家好,小丽今天来为大家解答左边绿右边红左右相遇起凉风打一字以下问题,左边绿,右边红相遇起凉风,(打一字)很多人还不知道,现在让我们一起
大家好,小美今天来为大家解答提高语文成绩的办法有哪些以下问题,提高语文成绩具体措施很多人还不知道,现在让我们一起来看看吧!1、快速提
大家好,小豪今天来为大家解答女生网名可爱超萌清新2字以下问题,网名2021最新版的女生可爱2字很多人还不知道,现在让我们一起来看看吧!1、漠
小伙伴们,下昼好今天给人人带来的常识相关考点是【刑法之自首】供人人储蓄进修一、概念。 自首是指犯罪后主动投案,向公安、司法机关或
Copyright 2024.依依自媒体,让大家了解更多图文资讯!